{"id":14,"date":"2020-12-15T11:01:33","date_gmt":"2020-12-15T10:01:33","guid":{"rendered":"https:\/\/www.amypore.com\/?page_id=14"},"modified":"2026-09-25T13:11:14","modified_gmt":"2026-09-25T11:11:14","slug":"identification-et-mecanisme","status":"publish","type":"page","link":"https:\/\/www.amypore.com\/en\/identification-et-mecanisme\/","title":{"rendered":"New Therapeutic Strategy"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"14\" class=\"elementor elementor-14\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-37dccb8 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"37dccb8\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[{&quot;jet_parallax_layout_image&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;_id&quot;:&quot;fa2e797&quot;,&quot;jet_parallax_layout_image_tablet&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_image_mobile&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_speed&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:50,&quot;sizes&quot;:[]},&quot;jet_parallax_layout_type&quot;:&quot;scroll&quot;,&quot;jet_parallax_layout_direction&quot;:&quot;1&quot;,&quot;jet_parallax_layout_fx_direction&quot;:null,&quot;jet_parallax_layout_z_index&quot;:0,&quot;jet_parallax_layout_bg_x&quot;:50,&quot;jet_parallax_layout_bg_x_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_x_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y&quot;:50,&quot;jet_parallax_layout_bg_y_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size&quot;:&quot;auto&quot;,&quot;jet_parallax_layout_bg_size_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_animation_prop&quot;:&quot;transform&quot;,&quot;jet_parallax_layout_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;]}],&quot;background_background&quot;:&quot;classic&quot;,&quot;background_motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;background_motion_fx_translateX_effect&quot;:&quot;yes&quot;,&quot;background_motion_fx_translateX_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:4,&quot;sizes&quot;:[]},&quot;background_motion_fx_translateX_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}},&quot;background_motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-a6329f6\" data-id=\"a6329f6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d91c109 elementor-widget elementor-widget-heading\" data-id=\"d91c109\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Notre Science<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c25e817 elementor-widget elementor-widget-heading\" data-id=\"c25e817\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Nouvelle Strat\u00e9gie Th\u00e9rapeutique<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aff4ef6 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"aff4ef6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-461b6f6\" data-id=\"461b6f6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a36cd06 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"a36cd06\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[{&quot;jet_parallax_layout_image&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;_id&quot;:&quot;55c9268&quot;,&quot;jet_parallax_layout_image_tablet&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_image_mobile&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_speed&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:50,&quot;sizes&quot;:[]},&quot;jet_parallax_layout_type&quot;:&quot;scroll&quot;,&quot;jet_parallax_layout_direction&quot;:&quot;1&quot;,&quot;jet_parallax_layout_fx_direction&quot;:null,&quot;jet_parallax_layout_z_index&quot;:0,&quot;jet_parallax_layout_bg_x&quot;:50,&quot;jet_parallax_layout_bg_x_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_x_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y&quot;:50,&quot;jet_parallax_layout_bg_y_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size&quot;:&quot;auto&quot;,&quot;jet_parallax_layout_bg_size_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_animation_prop&quot;:&quot;transform&quot;,&quot;jet_parallax_layout_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;]}],&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-61f7893\" data-id=\"61f7893\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7cb8d17 elementor-section-full_width elementor-reverse-tablet elementor-reverse-mobile elementor-section-height-default elementor-section-height-default\" data-id=\"7cb8d17\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[{&quot;jet_parallax_layout_image&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;_id&quot;:&quot;9fbc18f&quot;,&quot;jet_parallax_layout_image_tablet&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_image_mobile&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_speed&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:50,&quot;sizes&quot;:[]},&quot;jet_parallax_layout_type&quot;:&quot;scroll&quot;,&quot;jet_parallax_layout_direction&quot;:&quot;1&quot;,&quot;jet_parallax_layout_fx_direction&quot;:null,&quot;jet_parallax_layout_z_index&quot;:0,&quot;jet_parallax_layout_bg_x&quot;:50,&quot;jet_parallax_layout_bg_x_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_x_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y&quot;:50,&quot;jet_parallax_layout_bg_y_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size&quot;:&quot;auto&quot;,&quot;jet_parallax_layout_bg_size_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_animation_prop&quot;:&quot;transform&quot;,&quot;jet_parallax_layout_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;]}]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-6f3c54e elementor-hidden-tablet elementor-hidden-phone\" data-id=\"6f3c54e\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-de0e66b\" data-id=\"de0e66b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-fbd0c19\" data-id=\"fbd0c19\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3a2d1e3 elementor-widget elementor-widget-heading\" data-id=\"3a2d1e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Une th\u00e9rapie membranaire qui cible les gangliosides<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1d2223b elementor-widget elementor-widget-heading\" data-id=\"1d2223b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Prot\u00e9inopathies et pores amylo\u00efdes<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b549cf elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"5b549cf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2572bac elementor-widget elementor-widget-text-editor\" data-id=\"2572bac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Ces maladies sont provoqu\u00e9es par des prot\u00e9ines qui s\u2019agr\u00e8gent : A\u03b2 pour la maladie d\u2019Alzheimer, \u03b1-synucl\u00e9ine pour la maladie de Parkinson, l\u2019amyline pour le diab\u00e8te de type II, et d\u2019autres encore dans la maladie de Charcot ou la maladie de Creutzfeldt-Jakob.<\/p><p>Ces prot\u00e9ines appartiennent \u00e0 la cat\u00e9gorie des prot\u00e9ines intrins\u00e8quement d\u00e9sordonn\u00e9es (IDPs), qui ne poss\u00e8dent pas de structure 3D stable, ce qui les rend difficiles \u00e0 cibler. Les IDPs repr\u00e9sentent 50&nbsp;% des prot\u00e9ines humaines. Elles peuvent s\u2019assembler de diff\u00e9rentes mani\u00e8res, sous forme d\u2019oligom\u00e8res, de fibres et de plaques amylo\u00efdes. Parmi ces structures, les oligom\u00e8res sont les formes les plus toxiques et celles qui apparaissent le plus pr\u00e9cocement au cours de la pathog\u00e9n\u00e8se.<\/p><p>Ces oligom\u00e8res, soit pr\u00e9form\u00e9s, soit assembl\u00e9s dans la membrane \u00e0 partir de monom\u00e8res ins\u00e9r\u00e9s, y cr\u00e9ent des pores. Dans les deux cas, la formation du pore d\u00e9pend d\u2019une interaction initiale avec les gangliosides, des lipides concentr\u00e9s dans des domaines particuliers de la membrane plasmique appel\u00e9s \u00ab&nbsp;rafts&nbsp;\u00bb, comme le montre la vid\u00e9o ci-dessous. Ces pores, appel\u00e9s \u00ab&nbsp;pores amylo\u00efdes&nbsp;\u00bb, sont perm\u00e9ables au calcium. Les ions Ca<sup>2+<\/sup> s\u2019accumulent alors dans la cellule, d\u00e9clenchant une cascade toxique qui provoque la mort cellulaire.<\/p><p>Ce m\u00e9canisme est commun \u00e0 de nombreuses maladies impliquant des IDPs. Les gangliosides \u00e9tant une cible privil\u00e9gi\u00e9e des IDPs impliqu\u00e9es dans la formation des pores amylo\u00efdes, AmyPore est la premi\u00e8re biotech \u00e0 cibler les gangliosides.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c576c9 elementor-widget elementor-widget-html\" data-id=\"4c576c9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"amy-mecanisme\"><video id=\"amy-mecanisme-video\" src=\"https:\/\/www.amypore.com\/wp-content\/uploads\/2026\/09\/amyp53-mecanisme-1280.mp4\" poster=\"https:\/\/www.amypore.com\/wp-content\/uploads\/2026\/09\/amyp53-mecanisme-poster.jpg\" muted loop playsinline controls preload=\"none\"><\/video><\/div><style>.amy-mecanisme{width:100%;}.amy-mecanisme video{width:100%;height:auto;display:block;border-radius:6px;background:#f4f2ee;box-shadow:0 10px 30px rgba(0,0,0,.18);}<\/style><script>(function(){var v=document.getElementById(\"amy-mecanisme-video\");if(!v)return;var mq=window.matchMedia&&window.matchMedia(\"(prefers-reduced-motion: reduce)\");if(mq&&mq.matches)return;if(!(\"IntersectionObserver\" in window))return;var io=new IntersectionObserver(function(es){es.forEach(function(e){if(e.isIntersecting){var p=v.play();if(p&&p.catch)p.catch(function(){});io.disconnect();}});},{threshold:0.35});io.observe(v);})();<\/script>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cf722ce elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"cf722ce\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[{&quot;jet_parallax_layout_image&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;_id&quot;:&quot;64d606a&quot;,&quot;jet_parallax_layout_image_tablet&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_image_mobile&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_speed&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:50,&quot;sizes&quot;:[]},&quot;jet_parallax_layout_type&quot;:&quot;scroll&quot;,&quot;jet_parallax_layout_direction&quot;:&quot;1&quot;,&quot;jet_parallax_layout_fx_direction&quot;:null,&quot;jet_parallax_layout_z_index&quot;:0,&quot;jet_parallax_layout_bg_x&quot;:50,&quot;jet_parallax_layout_bg_x_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_x_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y&quot;:50,&quot;jet_parallax_layout_bg_y_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size&quot;:&quot;auto&quot;,&quot;jet_parallax_layout_bg_size_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_animation_prop&quot;:&quot;transform&quot;,&quot;jet_parallax_layout_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;]}],&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-ca8a96c\" data-id=\"ca8a96c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f9a1c7f elementor-widget elementor-widget-heading\" data-id=\"f9a1c7f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Comprendre le m\u00e9canisme des maladies d\u2019Alzheimer et de Parkinson<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0a99eee elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"0a99eee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-834e4e1 elementor-widget elementor-widget-text-editor\" data-id=\"834e4e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Nos chercheurs, gr\u00e2ce \u00e0 leur expertise et \u00e0 leur connaissance de la composition des membranes cellulaires, ont \u00e9lucid\u00e9 le code biologique qui contr\u00f4le la formation de ces pores amylo\u00efdes. Ils ont ainsi pu mod\u00e9liser, \u00e0 l\u2019\u00e9chelle atomique, le processus commun et complet de formation des pores amylo\u00efdes des prot\u00e9ines A\u03b2, pour la maladie d\u2019Alzheimer, et \u03b1-synucl\u00e9ine, pour la maladie de Parkinson.<\/p><p>L\u2019entr\u00e9e massive et permanente d\u2019ions Ca<sup>2+<\/sup> d\u00e9clenche une cascade neurotoxique dans laquelle on retrouve les marqueurs classiques de ces maladies&nbsp;: l\u2019hyperphosphorylation de la prot\u00e9ine Tau et le stress oxydatif mitochondrial. \u00c0 terme, les cellules subissent des d\u00e9r\u00e8glements fonctionnels majeurs aboutissant \u00e0 leur d\u00e9g\u00e9n\u00e9rescence, puis \u00e0 la mort cellulaire.<\/p><p>Les chercheurs d\u2019AmyPore ont d\u00e9couvert cette \u00e9tape essentielle, commune aux deux pathologies. Chez de nombreux patients, les pathologies A\u03b2 et \u03b1-synucl\u00e9ine coexistent&nbsp;: cibler leur m\u00e9canisme commun permet d\u2019agir sur les deux \u00e0 la fois.<\/p><p>\u00c0 l\u2019heure actuelle, AmyPore est la seule soci\u00e9t\u00e9 dont la mol\u00e9cule emp\u00eache la formation des pores amylo\u00efdes&nbsp;: AmyP53, son premier peptide adaptatif au m\u00e9canisme d\u2019action r\u00e9volutionnaire, un v\u00e9ritable \u00ab&nbsp;game changer&nbsp;\u00bb.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-08a201b elementor-mobile-align-justify elementor-widget elementor-widget-button\" data-id=\"08a201b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.amypore.com\/la-solution\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">D\u00e9couvrir nos solutions<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-4947440\" data-id=\"4947440\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-16903a6 elementor-widget elementor-widget-html\" data-id=\"16903a6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"amy-pore\"><video id=\"amy-pore-video\" src=\"https:\/\/www.amypore.com\/wp-content\/uploads\/2026\/09\/amyp53-3d-f3-web.mp4\" poster=\"https:\/\/www.amypore.com\/wp-content\/uploads\/2026\/09\/amyp53-3d-f3-poster.jpg\" muted loop playsinline controls preload=\"none\"><\/video><\/div><style>.amy-pore{width:100%;}.amy-pore video{width:100%;height:auto;display:block;border-radius:6px;background:#f4f2ee;box-shadow:0 10px 30px rgba(0,0,0,.18);}<\/style><script>(function(){var v=document.getElementById(\"amy-pore-video\");if(!v)return;var mq=window.matchMedia&&window.matchMedia(\"(prefers-reduced-motion: reduce)\");if(mq&&mq.matches)return;if(!(\"IntersectionObserver\" in window))return;var io=new IntersectionObserver(function(es){es.forEach(function(e){if(e.isIntersecting){var p=v.play();if(p&&p.catch)p.catch(function(){});io.disconnect();}});},{threshold:0.35});io.observe(v);})();<\/script>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Notre Science Nouvelle Strat\u00e9gie Th\u00e9rapeutique Une th\u00e9rapie membranaire qui cible les gangliosides Prot\u00e9inopathies et pores amylo\u00efdes Ces maladies sont provoqu\u00e9es par des prot\u00e9ines qui s\u2019agr\u00e8gent : A\u03b2 pour la maladie d\u2019Alzheimer, \u03b1-synucl\u00e9ine pour la maladie de Parkinson, l\u2019amyline pour le diab\u00e8te de type II, et d\u2019autres encore dans la maladie de Charcot ou la maladie [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-14","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.amypore.com\/en\/wp-json\/wp\/v2\/pages\/14","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.amypore.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.amypore.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.amypore.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.amypore.com\/en\/wp-json\/wp\/v2\/comments?post=14"}],"version-history":[{"count":0,"href":"https:\/\/www.amypore.com\/en\/wp-json\/wp\/v2\/pages\/14\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.amypore.com\/en\/wp-json\/wp\/v2\/media?parent=14"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}