{"id":15,"date":"2020-12-15T11:02:05","date_gmt":"2020-12-15T10:02:05","guid":{"rendered":"https:\/\/www.amypore.com\/?page_id=15"},"modified":"2026-10-05T12:04:38","modified_gmt":"2026-10-05T10:04:38","slug":"la-solution","status":"publish","type":"page","link":"https:\/\/www.amypore.com\/en\/la-solution\/","title":{"rendered":"Our Solutions"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"15\" class=\"elementor elementor-15\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-386baf9 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"386baf9\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[{&quot;jet_parallax_layout_image&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;_id&quot;:&quot;fa2e797&quot;,&quot;jet_parallax_layout_image_tablet&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_image_mobile&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_speed&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:50,&quot;sizes&quot;:[]},&quot;jet_parallax_layout_type&quot;:&quot;scroll&quot;,&quot;jet_parallax_layout_direction&quot;:&quot;1&quot;,&quot;jet_parallax_layout_fx_direction&quot;:null,&quot;jet_parallax_layout_z_index&quot;:0,&quot;jet_parallax_layout_bg_x&quot;:50,&quot;jet_parallax_layout_bg_x_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_x_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y&quot;:50,&quot;jet_parallax_layout_bg_y_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size&quot;:&quot;auto&quot;,&quot;jet_parallax_layout_bg_size_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_animation_prop&quot;:&quot;transform&quot;,&quot;jet_parallax_layout_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;]}],&quot;background_background&quot;:&quot;classic&quot;,&quot;background_motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;background_motion_fx_translateX_effect&quot;:&quot;yes&quot;,&quot;background_motion_fx_translateX_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:4,&quot;sizes&quot;:[]},&quot;background_motion_fx_translateX_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}},&quot;background_motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-6d422ef\" data-id=\"6d422ef\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ad63b5f elementor-widget elementor-widget-heading\" data-id=\"ad63b5f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Notre Science<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a2aafac elementor-widget elementor-widget-heading\" data-id=\"a2aafac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Nos Solutions<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-19e2b62 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"19e2b62\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-8f4bea6\" data-id=\"8f4bea6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fb62bfa elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"fb62bfa\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[{&quot;jet_parallax_layout_image&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;_id&quot;:&quot;55c9268&quot;,&quot;jet_parallax_layout_image_tablet&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_image_mobile&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_speed&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:50,&quot;sizes&quot;:[]},&quot;jet_parallax_layout_type&quot;:&quot;scroll&quot;,&quot;jet_parallax_layout_direction&quot;:&quot;1&quot;,&quot;jet_parallax_layout_fx_direction&quot;:null,&quot;jet_parallax_layout_z_index&quot;:0,&quot;jet_parallax_layout_bg_x&quot;:50,&quot;jet_parallax_layout_bg_x_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_x_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y&quot;:50,&quot;jet_parallax_layout_bg_y_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size&quot;:&quot;auto&quot;,&quot;jet_parallax_layout_bg_size_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_animation_prop&quot;:&quot;transform&quot;,&quot;jet_parallax_layout_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;]}],&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-456e0b8\" data-id=\"456e0b8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7152779 elementor-section-full_width elementor-reverse-tablet elementor-reverse-mobile elementor-section-height-default elementor-section-height-default\" data-id=\"7152779\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[{&quot;jet_parallax_layout_image&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;_id&quot;:&quot;9fbc18f&quot;,&quot;jet_parallax_layout_image_tablet&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_image_mobile&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_speed&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:50,&quot;sizes&quot;:[]},&quot;jet_parallax_layout_type&quot;:&quot;scroll&quot;,&quot;jet_parallax_layout_direction&quot;:&quot;1&quot;,&quot;jet_parallax_layout_fx_direction&quot;:null,&quot;jet_parallax_layout_z_index&quot;:0,&quot;jet_parallax_layout_bg_x&quot;:50,&quot;jet_parallax_layout_bg_x_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_x_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y&quot;:50,&quot;jet_parallax_layout_bg_y_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size&quot;:&quot;auto&quot;,&quot;jet_parallax_layout_bg_size_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_animation_prop&quot;:&quot;transform&quot;,&quot;jet_parallax_layout_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;]}]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-986a18d\" data-id=\"986a18d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-deaec05 elementor-widget elementor-widget-heading\" data-id=\"deaec05\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">AmyP53, un candidat m\u00e9dicament first-in-class<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b02e7f3 elementor-widget elementor-widget-heading\" data-id=\"b02e7f3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Emp\u00eacher la formation des pores amylo\u00efdes, cibler l\u2019\u00e9tape-cl\u00e9 de la pathog\u00e9n\u00e8se<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c826b0e amy-lead elementor-widget elementor-widget-text-editor\" data-id=\"c826b0e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Plut\u00f4t que de viser les prot\u00e9ines pathog\u00e8nes elles-m\u00eames, d\u00e9pourvues de structure stable et donc difficiles \u00e0 atteindre, AmyP53, un peptide adaptatif, cible leur point d\u2019ancrage dans la membrane&nbsp;: les gangliosides. Une approche enti\u00e8rement nouvelle, bas\u00e9e sur la flexibilit\u00e9 conformationnelle du peptide, jamais tent\u00e9e jusqu\u2019ici.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6a7b847 amy-stats-w elementor-widget elementor-widget-html\" data-id=\"6a7b847\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"amy-stats\">\n<div class=\"amy-stat\"><span class=\"amy-stat-n\">1<sup>er<\/sup><\/span><span class=\"amy-stat-l\">peptide ciblant les gangliosides impliqu\u00e9s dans les maladies d\u2019Alzheimer et de Parkinson<\/span><\/div>\n<div class=\"amy-stat\"><span class=\"amy-stat-n\">12<\/span><span class=\"amy-stat-l\">acides amin\u00e9s naturels&nbsp;: un peptide court et facile \u00e0 synth\u00e9tiser<\/span><\/div>\n<div class=\"amy-stat\"><span class=\"amy-stat-n\">2<\/span><span class=\"amy-stat-l\">maladies cibl\u00e9es par une m\u00eame mol\u00e9cule&nbsp;: Alzheimer et Parkinson<\/span><\/div>\n<div class=\"amy-stat\"><span class=\"amy-stat-n\">5<\/span><span class=\"amy-stat-l\">territoires couverts par le brevet EP14305353&nbsp;: Europe, \u00c9tats-Unis, Canada, Chine, Japon<\/span><\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-83a9b60 elementor-widget elementor-widget-heading\" data-id=\"83a9b60\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">\u2022 Bloquer la cascade neurotoxique en emp\u00eachant la formation des pores amylo\u00efdes dans la membrane des cellules du cerveau<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-15d5e76 elementor-widget elementor-widget-text-editor\" data-id=\"15d5e76\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Pour s\u2019assembler en pores, les prot\u00e9ines A\u03b2 (maladie d\u2019Alzheimer) et \u03b1-synucl\u00e9ine (maladie de Parkinson) doivent d\u2019abord se fixer sur des gangliosides sp\u00e9cifiques de la membrane&nbsp;: GM1 dans la maladie d\u2019Alzheimer, GM3 dans la maladie de Parkinson. AmyP53 se lie \u00e0 ces gangliosides et emp\u00eache cette fixation. Priv\u00e9es de leur point d\u2019ancrage, les prot\u00e9ines ne peuvent plus s\u2019oligom\u00e9riser dans la membrane&nbsp;: pas de pore, pas d\u2019entr\u00e9e de calcium, pas de cascade neurotoxique.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9385987 elementor-widget elementor-widget-heading\" data-id=\"9385987\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">\u2022 Un cahier des charges innovant<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5397ce1 elementor-widget elementor-widget-text-editor\" data-id=\"5397ce1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La conception d\u2019AmyP53 a int\u00e9gr\u00e9 d\u00e8s l\u2019origine de multiples param\u00e8tres biochimiques, biophysiques et pharmacologiques, afin d\u2019\u00e9viter les \u00e9cueils classiques du d\u00e9veloppement de candidats m\u00e9dicaments.<\/p><p>AmyP53 est issu du d\u00e9cryptage d\u2019un code biologique&nbsp;: celui qui gouverne la reconnaissance des gangliosides par les prot\u00e9ines amylo\u00efdes. Il a ainsi \u00e9t\u00e9 con\u00e7u pour se fixer sur sa cible avec une haute sp\u00e9cificit\u00e9, rester stable et \u00eatre administr\u00e9 par voie nasale. Sa petite taille en fait un peptide facile \u00e0 synth\u00e9tiser.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-671f05a elementor-widget elementor-widget-heading\" data-id=\"671f05a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">\u2022 AmyP53 est le premier repr\u00e9sentant d\u2019une nouvelle classe th\u00e9rapeutique<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-154b178 elementor-widget elementor-widget-text-editor\" data-id=\"154b178\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>En ciblant un m\u00e9canisme pathologique commun, AmyP53 est la premi\u00e8re solution th\u00e9rapeutique sp\u00e9cifiquement con\u00e7ue pour traiter deux maladies neurod\u00e9g\u00e9n\u00e9ratives majeures&nbsp;: Alzheimer et Parkinson.<\/p><p>AmyP53 ouvre ainsi une nouvelle classe de m\u00e9dicaments, dont le potentiel s\u2019\u00e9tend \u00e0 d\u2019autres pathologies impliquant des prot\u00e9ines intrins\u00e8quement d\u00e9sordonn\u00e9es et des gangliosides.<\/p><p>La vid\u00e9o ci-dessous compare une membrane sans protection, o\u00f9 les prot\u00e9ines amylo\u00efdes forment des pores, et une membrane prot\u00e9g\u00e9e par AmyP53.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5c15669 elementor-widget elementor-widget-html\" data-id=\"5c15669\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"amy-solution\"><video id=\"amy-solution-video\" src=\"https:\/\/www.amypore.com\/wp-content\/uploads\/2026\/09\/amyp53-3d-f4-web.mp4\" poster=\"https:\/\/www.amypore.com\/wp-content\/uploads\/2026\/09\/amyp53-3d-f4-poster.jpg\" muted loop playsinline controls preload=\"none\"><\/video><\/div><style>.amy-solution{width:100%;}.amy-solution video{width:100%;height:auto;display:block;border-radius:6px;background:#f4f2ee;box-shadow:0 10px 30px rgba(0,0,0,.25);}<\/style><script>(function(){var v=document.getElementById(\"amy-solution-video\");if(!v)return;var mq=window.matchMedia&&window.matchMedia(\"(prefers-reduced-motion: reduce)\");if(mq&&mq.matches)return;if(!(\"IntersectionObserver\" in window))return;var io=new IntersectionObserver(function(es){es.forEach(function(e){if(e.isIntersecting){var p=v.play();if(p&&p.catch)p.catch(function(){});io.disconnect();}});},{threshold:0.3});io.observe(v);})();<\/script>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c5f366c amy-sec-light elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c5f366c\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3d04e54\" data-id=\"3d04e54\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e933249 elementor-widget elementor-widget-heading\" data-id=\"e933249\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Comment agit AmyP53<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0c8cac8 elementor-widget elementor-widget-heading\" data-id=\"0c8cac8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Un seul point de blocage, en amont de la cascade<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6e9de6f elementor-widget elementor-widget-html\" data-id=\"6e9de6f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"amy-steps\">\n<div class=\"amy-step\"><span class=\"amy-step-n\">1<\/span><h4>Fixation<\/h4><p>Les prot\u00e9ines A\u03b2 ou \u03b1-synucl\u00e9ine se fixent sur les gangliosides concentr\u00e9s dans les rafts de la membrane des cellules du cerveau.<\/p><\/div>\n<div class=\"amy-step\"><span class=\"amy-step-n\">2<\/span><h4>Formation du pore<\/h4><p>Ancr\u00e9es dans la membrane, elles s\u2019assemblent en oligom\u00e8res qui forment des pores perm\u00e9ables au calcium. L\u2019afflux de Ca<sup>2+<\/sup> d\u00e9clenche la cascade neurotoxique&nbsp;: hyperphosphorylation de Tau, stress mitochondrial, mort neuronale.<\/p><\/div>\n<div class=\"amy-step amy-step-on\"><span class=\"amy-step-n\">3<\/span><h4>Blocage par AmyP53<\/h4><p>AmyP53 occupe les gangliosides en amont&nbsp;: les prot\u00e9ines ne peuvent plus s\u2019y fixer. Pas de pore, pas d\u2019afflux de Ca<sup>2+<\/sup>, pas de cascade neurotoxique.<\/p><\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c2fc14e elementor-widget elementor-widget-heading\" data-id=\"c2fc14e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">L\u2019angle mort des approches mono-cibles<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-75e2e8a elementor-widget elementor-widget-heading\" data-id=\"75e2e8a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Une co-pathologie ignor\u00e9e par les traitements actuels<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27609db elementor-widget elementor-widget-html\" data-id=\"27609db\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"amy-copat\">\n<div class=\"amy-copat-l\">\n<div class=\"amy-copat-stat\"><span class=\"amy-copat-n\">~50&nbsp;%<\/span><p>des patients atteints de la maladie d\u2019Alzheimer pr\u00e9sentent aussi une <strong>pathologie \u03b1-synucl\u00e9ine<\/strong>, la signature de la maladie de Parkinson.<\/p><\/div>\n<div class=\"amy-copat-stat\"><span class=\"amy-copat-n\"><span>70 \u00e0<\/span><span>81&nbsp;%<\/span><\/span><p>des cas d\u2019Alzheimer avanc\u00e9 et de maladie \u00e0 corps de Lewy pr\u00e9sentent <strong>au moins une autre prot\u00e9inopathie<\/strong>.<\/p><\/div>\n<div class=\"amy-copat-box\"><ul><li>Cibler une seule prot\u00e9ine (A\u03b2 <em>ou<\/em> \u03b1-synucl\u00e9ine) laisse de nombreux patients partiellement trait\u00e9s.<\/li><li><strong>AmyP53 agit sur le m\u00e9canisme commun&nbsp;:<\/strong> il cible les deux pathologies \u00e0 la fois.<\/li><\/ul><\/div>\n<\/div>\n<div class=\"amy-copat-r\"><div class=\"amy-venn\">\n<svg viewBox=\"0 0 480 380\" role=\"img\" aria-hidden=\"true\">\n<defs>\n<linearGradient id=\"amyGA\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" stop-color=\"#BFDCE7\"\/><stop offset=\"1\" stop-color=\"#78AEC2\"\/><\/linearGradient>\n<linearGradient id=\"amyGS\" x1=\"1\" y1=\"0\" x2=\"0\" y2=\"1\"><stop offset=\"0\" stop-color=\"#E4E3EE\"\/><stop offset=\"1\" stop-color=\"#B9B6CF\"\/><\/linearGradient>\n<filter id=\"amySh\" x=\"-20%\" y=\"-20%\" width=\"140%\" height=\"140%\"><feDropShadow dx=\"0\" dy=\"6\" stdDeviation=\"10\" flood-color=\"#080024\" flood-opacity=\".12\"\/><\/filter>\n<\/defs>\n<g filter=\"url(#amySh)\">\n<circle cx=\"315\" cy=\"225\" r=\"145\" fill=\"url(#amyGS)\" fill-opacity=\".85\"\/>\n<ellipse cx=\"165\" cy=\"210\" rx=\"120\" ry=\"135\" fill=\"url(#amyGA)\" fill-opacity=\".75\"\/>\n<\/g>\n<circle cx=\"315\" cy=\"225\" r=\"145\" fill=\"none\" stroke=\"#fff\" stroke-width=\"2.5\"\/>\n<ellipse cx=\"165\" cy=\"210\" rx=\"120\" ry=\"135\" fill=\"none\" stroke=\"#fff\" stroke-width=\"2.5\"\/>\n<\/svg>\n<span class=\"amy-venn-chip amy-venn-chip-a\" style=\"left:34%;top:9%\">A\u03b2<\/span>\n<span class=\"amy-venn-chip amy-venn-chip-s\" style=\"left:72%;top:9%\">\u03b1-synucl\u00e9ine<\/span>\n<span class=\"amy-venn-l\" style=\"left:21.5%;top:55%\">Alzheimer<\/span>\n<span class=\"amy-venn-l amy-venn-mix\" style=\"left:47.6%;top:59%\"><strong>Formes mixtes<\/strong><small>Maladies \u00e0 corps de Lewy<\/small><\/span>\n<span class=\"amy-venn-l\" style=\"left:79%;top:62%\">Parkinson<\/span>\n<\/div><p class=\"amy-venn-leg\"><strong>Formes mixtes&nbsp;:<\/strong> maladies \u00e0 corps de Lewy<\/p><p class=\"amy-venn-cap\">Chevauchement des pathologies Alzheimer et Parkinson<\/p><\/div>\n<\/div>\n<p class=\"amy-copat-src\">Donn\u00e9es issues d\u2019\u00e9tudes post-mortem. Sources&nbsp;: <a href=\"https:\/\/academic.oup.com\/brain\/article\/141\/7\/2181\/5033683\" target=\"_blank\" rel=\"noopener\">Robinson J.L. et al., <em>Brain<\/em>, 2018<\/a><br><a href=\"https:\/\/journals.sagepub.com\/doi\/10.3233\/JPD-202323\" target=\"_blank\" rel=\"noopener\">Compta Y. &amp; Revesz T., <em>Journal of Parkinson\u2019s Disease<\/em>, 2021<\/a>.<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2256c76 elementor-widget elementor-widget-heading\" data-id=\"2256c76\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Ce qui diff\u00e9rencie AmyP53<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe59d72 amy-lead-d elementor-widget elementor-widget-text-editor\" data-id=\"fe59d72\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Malgr\u00e9 des d\u00e9cennies de recherche et des milliards investis par l\u2019industrie pharmaceutique, aucun traitement ne permet aujourd\u2019hui d\u2019arr\u00eater la progression des maladies d\u2019Alzheimer et de Parkinson. AmyP53 se distingue des approches actuelles sur chacun des points cl\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3242dbb elementor-widget elementor-widget-html\" data-id=\"3242dbb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<table class=\"amy-cmp\">\n<thead><tr><th><\/th><th>Approches classiques ciblant les prot\u00e9ines amylo\u00efdes<\/th><th class=\"amy-cmp-us\">AmyP53<\/th><\/tr><\/thead>\n<tbody>\n<tr><th>Cible<\/th><td><span class=\"amy-cmp-lbl\">Approches classiques<\/span>Les prot\u00e9ines amylo\u00efdes ou leurs agr\u00e9gats (plaques)<\/td><td class=\"amy-cmp-us\"><span class=\"amy-cmp-lbl\">AmyP53<\/span>Les gangliosides, point d\u2019ancrage membranaire commun des prot\u00e9ines amylo\u00efdes<\/td><\/tr>\n<tr><th>Stade d\u2019action<\/th><td><span class=\"amy-cmp-lbl\">Approches classiques<\/span>Apr\u00e8s formation des agr\u00e9gats<\/td><td class=\"amy-cmp-us\"><span class=\"amy-cmp-lbl\">AmyP53<\/span>\u00c0 l\u2019\u00e9tape la plus pr\u00e9coce, avant la formation des pores<\/td><\/tr>\n<tr><th>Indications<\/th><td><span class=\"amy-cmp-lbl\">Approches classiques<\/span>Une maladie par mol\u00e9cule<\/td><td class=\"amy-cmp-us\"><span class=\"amy-cmp-lbl\">AmyP53<\/span>Alzheimer et Parkinson avec une m\u00eame mol\u00e9cule, qui cible aussi les co-pathologies<\/td><\/tr>\n<tr><th>Nature<\/th><td><span class=\"amy-cmp-lbl\">Approches classiques<\/span>Essentiellement des anticorps monoclonaux<\/td><td class=\"amy-cmp-us\"><span class=\"amy-cmp-lbl\">AmyP53<\/span>Un peptide de 12 acides amin\u00e9s naturels, facile \u00e0 synth\u00e9tiser<\/td><\/tr>\n<tr><th>Administration<\/th><td><span class=\"amy-cmp-lbl\">Approches classiques<\/span>Perfusion intraveineuse ou injection<\/td><td class=\"amy-cmp-us\"><span class=\"amy-cmp-lbl\">AmyP53<\/span>Spray nasal, non invasif<\/td><\/tr>\n<\/tbody><\/table>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8d0e301 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8d0e301\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cfd72a7\" data-id=\"cfd72a7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9c6b7fd elementor-widget elementor-widget-heading\" data-id=\"9c6b7fd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">R\u00e9sultats pr\u00e9cliniques<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-000a1e1 elementor-widget elementor-widget-heading\" data-id=\"000a1e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Des preuves obtenues sur cellules et sur mod\u00e8les animaux<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7862fa7 elementor-widget elementor-widget-html\" data-id=\"7862fa7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"amy-cards\">\n<div class=\"amy-card\"><h4>Stabilit\u00e9 et innocuit\u00e9<\/h4><p>Forte stabilit\u00e9 chimique et biologique. Absence de toxicit\u00e9 aux doses maximales test\u00e9es sur les neurones, les astrocytes et les cellules endoth\u00e9liales.<\/p><\/div>\n<div class=\"amy-card\"><h4>Tol\u00e9rance<\/h4><p>Aucune toxicit\u00e9 aux doses maximales test\u00e9es sur les mod\u00e8les animaux (rongeurs et non-rongeurs). Aucune r\u00e9action inflammatoire apr\u00e8s administrations intranasales r\u00e9p\u00e9t\u00e9es. Excellent profil de s\u00e9curit\u00e9.<\/p><\/div>\n<div class=\"amy-card\"><h4>M\u00e9canisme valid\u00e9<\/h4><p>AmyP53 inhibe la toxicit\u00e9 des prot\u00e9ines A\u03b2 et \u03b1-synucl\u00e9ine, la formation des pores amylo\u00efdes et les flux de Ca<sup>2+<\/sup> impliqu\u00e9s dans les maladies d\u2019Alzheimer et de Parkinson.<\/p><\/div>\n<div class=\"amy-card\"><h4>Proof of Concept<\/h4><p>AmyP53 a d\u00e9montr\u00e9 son efficacit\u00e9 th\u00e9rapeutique dans des mod\u00e8les de la maladie d\u2019Alzheimer et de la maladie de Parkinson. Dans un mod\u00e8le animal de la maladie de Parkinson induit par des oligom\u00e8res d\u2019\u03b1-synucl\u00e9ine, il pr\u00e9vient notamment la perte des neurones dopaminergiques.<\/p><\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3111a27 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3111a27\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-22fc97f\" data-id=\"22fc97f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-15ce1da elementor-widget elementor-widget-heading\" data-id=\"15ce1da\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Stade de d\u00e9veloppement<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8c48e51 elementor-widget elementor-widget-heading\" data-id=\"8c48e51\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Du d\u00e9cryptage d\u2019un code biologique \u00e0 l\u2019essai clinique<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-44352d6 elementor-widget elementor-widget-html\" data-id=\"44352d6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ol class=\"amy-tl\">\n<li class=\"amy-tl-done\"><span class=\"amy-tl-tag\">R\u00e9alis\u00e9<\/span><h4>D\u00e9couverte<\/h4><p>Nos chercheurs d\u00e9cryptent le code biologique qui contr\u00f4le la reconnaissance des gangliosides par les prot\u00e9ines amylo\u00efdes.<\/p><\/li>\n<li class=\"amy-tl-done\"><span class=\"amy-tl-tag\">R\u00e9alis\u00e9<\/span><h4>Brevet<\/h4><p>AmyP53 est prot\u00e9g\u00e9 par le brevet EP14305353&nbsp;: Europe, \u00c9tats-Unis, Canada, Chine, Japon.<\/p><\/li>\n<li class=\"amy-tl-done\"><span class=\"amy-tl-tag\">Achev\u00e9<\/span><h4>\u00c9tudes pr\u00e9cliniques<\/h4><p>L\u2019ensemble des \u00e9tudes pr\u00e9cliniques d\u2019AmyP53 est achev\u00e9.<\/p><\/li>\n<li class=\"amy-tl-next\"><span class=\"amy-tl-tag\">Prochaine \u00e9tape<\/span><h4>Essai de phase 1<\/h4><p>Premi\u00e8re administration d\u2019AmyP53 chez l\u2019homme.<\/p><\/li>\n<\/ol>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-60a930a elementor-section-full_width elementor-reverse-tablet elementor-reverse-mobile elementor-section-height-default elementor-section-height-default\" data-id=\"60a930a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[{&quot;jet_parallax_layout_image&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;_id&quot;:&quot;55c9268&quot;,&quot;jet_parallax_layout_image_tablet&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_image_mobile&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_speed&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:50,&quot;sizes&quot;:[]},&quot;jet_parallax_layout_type&quot;:&quot;scroll&quot;,&quot;jet_parallax_layout_direction&quot;:&quot;1&quot;,&quot;jet_parallax_layout_fx_direction&quot;:null,&quot;jet_parallax_layout_z_index&quot;:0,&quot;jet_parallax_layout_bg_x&quot;:50,&quot;jet_parallax_layout_bg_x_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_x_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y&quot;:50,&quot;jet_parallax_layout_bg_y_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size&quot;:&quot;auto&quot;,&quot;jet_parallax_layout_bg_size_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_animation_prop&quot;:&quot;transform&quot;,&quot;jet_parallax_layout_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;]}],&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-16b9a84\" data-id=\"16b9a84\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0118b73 elementor-widget elementor-widget-image\" data-id=\"0118b73\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"759\" height=\"1024\" src=\"https:\/\/www.amypore.com\/wp-content\/uploads\/2020\/12\/spray-759x1024.png\" class=\"attachment-large size-large wp-image-90\" alt=\"\" srcset=\"https:\/\/www.amypore.com\/wp-content\/uploads\/2020\/12\/spray-759x1024.png.webp 759w, https:\/\/www.amypore.com\/wp-content\/uploads\/2020\/12\/spray-600x810.png.webp 600w, https:\/\/www.amypore.com\/wp-content\/uploads\/2020\/12\/spray-222x300.png.webp 222w, https:\/\/www.amypore.com\/wp-content\/uploads\/2020\/12\/spray-768x1037.png.webp 768w, https:\/\/www.amypore.com\/wp-content\/uploads\/2020\/12\/spray.png.webp 800w\" sizes=\"(max-width: 759px) 100vw, 759px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-b18e84a\" data-id=\"b18e84a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4bcc897 elementor-widget elementor-widget-heading\" data-id=\"4bcc897\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Un spray nasal d\u00e9velopp\u00e9 avec Aptar Pharma pour les essais cliniques<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e68dae1 elementor-widget elementor-widget-heading\" data-id=\"e68dae1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">L\u2019administration nez-cerveau<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f14798b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"f14798b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5157568 elementor-widget elementor-widget-text-editor\" data-id=\"5157568\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>AmyP53 sera administr\u00e9 par spray nasal. Cette voie non invasive permet d\u2019atteindre directement le cerveau, par l\u2019interm\u00e9diaire du nerf olfactif et du nerf trijumeau. Elle offre un meilleur confort aux patients, \u00e0 leurs familles et aux soignants.<\/p><p>Pour concevoir ce dispositif, AmyPore a collabor\u00e9 avec <strong>Aptar Pharma<\/strong>, leader mondial des syst\u00e8mes d\u2019administration de m\u00e9dicaments par voie nasale. Six dispositifs ont \u00e9t\u00e9 \u00e9valu\u00e9s, dont deux sp\u00e9cifiquement con\u00e7us pour l\u2019administration nez-cerveau&nbsp;: les <strong>Neurospray\u2122<\/strong> et <strong>Neurospray\u2122 sans conservateur<\/strong>. Les r\u00e9sultats, publi\u00e9s dans la revue <em>Pharmaceutics<\/em> en 2026, montrent que&nbsp;:<\/p><ul><li>les Neurospray\u2122 d\u00e9posent jusqu\u2019\u00e0 84&nbsp;% du produit dans la r\u00e9gion olfactive et les cornets, nettement plus que les dispositifs commerciaux test\u00e9s&nbsp;;<\/li><li>AmyP53 est d\u00e9livr\u00e9 de fa\u00e7on quantitative et reproductible, et conserve intacte sa capacit\u00e9 \u00e0 reconna\u00eetre sa cible, les gangliosides&nbsp;;<\/li><li>chez le lapin, AmyP53 atteint le cerveau en 10&nbsp;minutes et y reste d\u00e9tectable 24&nbsp;heures apr\u00e8s l\u2019administration, sans exposition syst\u00e9mique significative.<\/li><\/ul><p>Ces r\u00e9sultats valident les dispositifs Neurospray\u2122 pour le d\u00e9veloppement clinique d\u2019AmyP53, en vue de l\u2019essai de phase&nbsp;1.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76ea426 elementor-widget elementor-widget-html\" data-id=\"76ea426\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"amy-links\"><a class=\"amy-btn\" href=\"https:\/\/doi.org\/10.3390\/pharmaceutics18080987\" target=\"_blank\" rel=\"noopener\">Lire la publication<\/a><a class=\"amy-btn amy-btn-o\" href=\"https:\/\/aptar.com\/en-us\/pharmaceutical\/delivery-routes\/nasal-system-drug-delivery-oindp\/nose-to-brain-drug-delivery\" target=\"_blank\" rel=\"noopener\">Aptar Pharma \u2013 Nose-to-Brain<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-07cedf4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"07cedf4\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cb4ccbd\" data-id=\"cb4ccbd\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a3c6e22 elementor-widget elementor-widget-html\" data-id=\"a3c6e22\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"amy-beyond\"><h4>Au-del\u00e0 d\u2019Alzheimer et de Parkinson<\/h4><p>Les gangliosides sont \u00e9galement impliqu\u00e9s dans d\u2019autres maladies neurod\u00e9g\u00e9n\u00e9ratives (scl\u00e9rose lat\u00e9rale amyotrophique, maladie de Creutzfeldt-Jakob), dans de nombreuses maladies infectieuses, dans les m\u00e9tastases de cancers et dans le diab\u00e8te de type&nbsp;2. Notre plateforme exploite ce potentiel.<\/p><a class=\"amy-btn\" href=\"https:\/\/www.amypore.com\/pipeline\/\">D\u00e9couvrir notre plateforme<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Notre Science Nos Solutions AmyP53, un candidat m\u00e9dicament first-in-class Emp\u00eacher la formation des pores amylo\u00efdes, cibler l\u2019\u00e9tape-cl\u00e9 de la pathog\u00e9n\u00e8se Plut\u00f4t que de viser les prot\u00e9ines pathog\u00e8nes elles-m\u00eames, d\u00e9pourvues de structure stable et donc difficiles \u00e0 atteindre, AmyP53, un peptide adaptatif, cible leur point d\u2019ancrage dans la membrane&nbsp;: les gangliosides. Une approche enti\u00e8rement nouvelle, bas\u00e9e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-15","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.amypore.com\/en\/wp-json\/wp\/v2\/pages\/15","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.amypore.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.amypore.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.amypore.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.amypore.com\/en\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":0,"href":"https:\/\/www.amypore.com\/en\/wp-json\/wp\/v2\/pages\/15\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.amypore.com\/en\/wp-json\/wp\/v2\/media?parent=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}