Our Science

Scientific publications

The work of AmyPore’s researchers, published in international scientific journals, underpins our approach: from amyloid pores to gangliosides, through to the first adaptive peptide, AmyP53.

A selection of our research

Published in international peer-reviewed journals

20peer-reviewed publications and books
6publications dedicated to AmyP53
2002–2026over 20 years of research on amyloid pores and gangliosides

Recent publications

AmyP53Pharmaceutics2026 · 18(8):987

An Optimal Spray Device for the Nose-to-Brain Delivery of AmyP53, an Adaptive Therapeutic Peptide for Alzheimer’s and Parkinson’s Diseases

Farias G, Chahinian H, Hauchard N, Brunet D, Fantini J, Yahi N, Fantini D, Aulas A

Read the article View abstract
AmyP53Neural Regeneration Research2026 · 21(6):2339-2340

Targeting gangliosides to treat Alzheimer’s and Parkinson’s diseases: A disruptive approach with the first-in-class peptide AmyP53

Fantini J, Yahi N

Read the article View abstract
AmyP53Scientific Reports2025 · 15(1):9144

Preclinical assessment of a ganglioside-targeted therapy for Parkinson’s disease with the first-in-class adaptive peptide AmyP53

Fantini J, Azzaz F, Aulas A, Chahinian H, Yahi N

Read the article View abstract

Selected publications

20 publications

2026
AmyP53Pharmaceutics2026 · 18(8):987

An Optimal Spray Device for the Nose-to-Brain Delivery of AmyP53, an Adaptive Therapeutic Peptide for Alzheimer’s and Parkinson’s Diseases

Farias G, Chahinian H, Hauchard N, Brunet D, Fantini J, Yahi N, Fantini D, Aulas A

Read the article View abstract
AmyP53Neural Regeneration Research2026 · 21(6):2339-2340

Targeting gangliosides to treat Alzheimer’s and Parkinson’s diseases: A disruptive approach with the first-in-class peptide AmyP53

Fantini J, Yahi N

Read the article View abstract
2025
AmyP53Scientific Reports2025 · 15(1):9144

Preclinical assessment of a ganglioside-targeted therapy for Parkinson’s disease with the first-in-class adaptive peptide AmyP53

Fantini J, Azzaz F, Aulas A, Chahinian H, Yahi N

Read the article View abstract
Adaptive peptidesPharmacology & Therapeutics2025 · 108797

Conformationally adaptive therapeutic peptides for diseases caused by intrinsically disordered proteins (IDPs). New paradigm for drug discovery: Target the target, not the arrow

Fantini J, Azzaz F, Di Scala C, Aulas A, Chahinian H, Yahi N

Read the article View abstract
MechanismsPhysiological Reviews2025 · 105(1):137-207

Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives

Incontro S, Musella ML, Sammari M, Di Scala C, Fantini J, Debanne D

Read the article View abstract
2023
AmyP53International Journal of Molecular Sciences2023 · 24(2):1760

AmyP53 Prevents the Formation of Neurotoxic β-Amyloid Oligomers through an Unprecedent Mechanism of Interaction with Gangliosides: Insights for Alzheimer’s Disease Therapy

Azzaz F, Chahinian H, Yahi N, Fantini J, Di Scala C

Read the article View abstract
2022
AmyP53International Journal of Molecular Sciences2022 · 23(21):13383

AmyP53, a Therapeutic Peptide Candidate for the Treatment of Alzheimer’s and Parkinson’s Disease: Safety, Stability, Pharmacokinetics Parameters and Nose-to Brain Delivery

Di Scala C, Armstrong N, Chahinian H, Chabrière E, Fantini J, Yahi N

Read the article View abstract
AmyP53Glycoconjugate Journal2022 · 39(1):1-11

Innovative treatment targeting gangliosides aimed at blocking the formation of neurotoxic α-synuclein oligomers in Parkinson’s disease

Yahi N, Di Scala C, Chahinian H, Fantini J

Read the article View abstract
2021
MechanismsInternational Journal of Molecular Sciences2021 · 22(21):11550

Gene Therapy Strategy for Alzheimer’s and Parkinson’s Diseases Aimed at Preventing the Formation of Neurotoxic Oligomers in SH-SY5Y Cells

El-Battari A, Rodriguez L, Chahinian H, Delézay O, Fantini J, Yahi N, Di Scala C

Read the article View abstract
2020
MechanismsProtein Science2020 · 29(8):1748-1759

Progress toward Alzheimer’s disease treatment: Leveraging the Achilles’ heel of Aβ oligomers?

Fantini J, Chahinian H, Yahi N

Read the article View abstract
2016
MechanismsScientific Reports2016 · 6:28781

Common molecular mechanism of amyloid pore formation by Alzheimer’s β-amyloid peptide and α-synuclein

Di Scala C, Yahi N, Boutemeur S, Flores A, Rodriguez L, Chahinian H, Fantini J

Read the article View abstract
Adaptive peptidesBiochimica et Biophysica Acta – Molecular Basis of Disease2016 · 1862(2):213-22

Broad neutralization of calcium-permeable amyloid pore channels with a chimeric Alzheimer/Parkinson peptide targeting brain gangliosides

Di Scala C, Yahi N, Flores A, Boutemeur S, Kourdougli N, Chahinian H, Fantini J

Read the article View abstract
MechanismsData in Brief2016 · 6:640-3

Comparison of the amyloid pore forming properties of rat and human Alzheimer’s beta-amyloid peptide 1-42: Calcium imaging data

Di Scala C, Yahi N, Flores A, Boutemeur S, Kourdougli N, Chahinian H, Fantini J

Read the article View abstract
2015
MechanismsAcademic Press (book)2015

Brain Lipids in Synaptic Function and Neurological Disease. Clues to Innovative Therapeutic Strategies for Brain Disorders

Fantini J, Yahi N

Read the article View abstract
2014
Adaptive peptidesPLoS One2014 · 9(8):e104751

Deciphering the glycolipid code of Alzheimer’s and Parkinson’s amyloid proteins allowed the creation of a universal ganglioside-binding peptide

Yahi N, Fantini J

Read the article View abstract
MechanismsBiochemistry2014 · 53(28):4489-502

Interaction of Alzheimer’s β-amyloid peptides with cholesterol: mechanistic insights into amyloid pore formation

Di Scala C, Chahinian H, Yahi N, Garmy N, Fantini J

Read the article View abstract
2011
MechanismsJournal of Molecular Biology2011 · 408(4):654-69

Molecular basis for the glycosphingolipid-binding specificity of α-synuclein: key role of tyrosine 39 in membrane insertion

Fantini J, Yahi N

Read the article View abstract
2010
MechanismsExpert Reviews in Molecular Medicine2010 · 12:e27

Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases

Fantini J, Yahi N

Read the article View abstract
2002
MechanismsJournal of Biological Chemistry2002 · 277(13):11292-6

Identification of a common sphingolipid-binding domain in Alzheimer, prion, and HIV-1 proteins

Mahfoud R, Garmy N, Maresca M, Yahi N, Puigserver A, Fantini J

Read the article View abstract