Our approach

Scientific publications

Progress toward Alzheimer's disease treatment: Leveraging the Achilles' heel of A-beta oligomers

J. Fantini, H. Chahinian & N. Yahi - Protein Science 2020

Common molecular mechanism of amyloid pore formation by Alzheimer's beta-amyloid peptide andalpha-synuclein

C. Di Scala, N. Yahi, S. Boutemeur, A. Flores , L. Rodriguez , H. Chahinian, J. Fantini - Scientific Reports 2016

Comparison of the amyloid pore forming properties of rat and human Alzheimer's beta-amyloid peptide 1-42: Calcium imaging data

C. Di Scala, N. Yahi, A.Flores, S. Boutemeur, N. Kourdougli, H. Chahinian, J. Fantini - Data Brief 2016

Broad neutralization of calcium-permeable amyloid pore channels with a chimeric Alzheimer/Parkinson peptide targeting brain gangliosides

C. Di Scala, N. Yahi, A.Flores, S. Boutemeur 1, N. Kourdougli 2, H. Chahinian, J. Fantini - BBA Molecular Basis of Disease 2016

Brain Lipids in Synaptic Function and Neurological Disease

J. Fantini & N. Yahi - Academic Press 2015

Deciphering the glycolipid code of Alzheimer's and Parkinson's amyloid proteins allowed the creation of a universal ganglioside-binding peptide

J. Fantini & N. Yahi - PLOS One 2014

Interaction of Alzheimer's beta-amyloid peptides with cholesterol: mechanistic insights into amyloid pore formation

C. Di Scala, H. Chahinian, N. Yahi, N. Garmy, J. Fantini - Biochemistry 2014

Molecular basis for the glycosphingolipid-binding specificity of alpha-synuclein: key role of tyrosine 39 in membrane insertion

J. Fantini & N. Yahi - J. Mol. Biol. 2011

Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases

J. Fantini & N. Yahi - Expert Rev Mol Med 2010

Identification of a common sphingolipid-binding domain in Alzheimer, prion, and HIV-1 proteins

R. Mahfoud , N. Garmy, M. Maresca, N. Yahi, A. Puigserver, J. Fantini - J. Biol. Chem. 2002