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Publications scientifiques

Conformationally adaptive therapeutic peptides for diseases caused by intrinsically disordered proteins (IDPs). New paradigm for drug discovery: Target the target, not the arrow

Jacques Fantini , Fodil Azzaz , Coralie Di Scala , Anaïs Aulas , Henri Chahinian , Nouara Yahi

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Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives

Salvatore Incontro, Maria Laura Musella, Malika Sammari, Coralie Di Scala, Jacques Fantini, Dominique Debanne

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Lipid rafts and human diseases: why we need to target gangliosides

Jacques Fantini

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AmyP53 Prevents the Formation of Neurotoxic β-Amyloid Oligomers through an Unprecedent Mechanism of Interaction with Gangliosides: Insights for Alzheimer's Disease Therapy

Fodil Azzaz , Henri Chahinian , Nouara Yahi , Jacques Fantini , Coralie Di Scala

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AmyP53, a Therapeutic Peptide Candidate for the Treatment of Alzheimer's and Parkinson's Disease: Safety, Stability, Pharmacokinetics Parameters and Nose-to Brain Delivery

Di Scala C, Armstrong N, Chahinian H, Chabrière E, Fantini J, Yahi N. AmyP53, a Therapeutic International Journal of Molecular Sciences 2022

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Gene Therapy Strategy for Alzheimer’s and Parkinson’s Diseases Aimed at Preventing the Formation of Neurotoxic Oligomers in SH-SY5Y Cells

Assou El-Battari , Léa Rodriguez , Henri Chahinian , Olivier Delézay , Jacques Fantini , Nouara Yahi , Coralie Di Scala

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Innovative treatment targeting gangliosides aimed at blocking the formation of neurotoxic α-synuclein oligomers in Parkinson’s disease

Nouara Yahi, Coralie Di Scala, Henri Chahinian & Jacques Fantini

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Progress toward Alzheimer's disease treatment: Leveraging the Achilles' heel of A-beta oligomers

J. Fantini, H. Chahinian & N. Yahi - Protein Science 2020

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Common molecular mechanism of amyloid pore formation by Alzheimer's beta-amyloid peptide andalpha-synuclein

C. Di Scala, N. Yahi, S. Boutemeur, A. Flores , L. Rodriguez , H. Chahinian, J. Fantini - Scientific Reports 2016

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Comparison of the amyloid pore forming properties of rat and human Alzheimer's beta-amyloid peptide 1-42: Calcium imaging data

C. Di Scala, N. Yahi, A.Flores, S. Boutemeur, N. Kourdougli, H. Chahinian, J. Fantini - Data Brief 2016

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Broad neutralization of calcium-permeable amyloid pore channels with a chimeric Alzheimer/Parkinson peptide targeting brain gangliosides

C. Di Scala, N. Yahi, A.Flores, S. Boutemeur 1, N. Kourdougli 2, H. Chahinian, J. Fantini - BBA Molecular Basis of Disease 2016

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Brain Lipids in Synaptic Function and Neurological Disease

J. Fantini & N. Yahi - Academic Press 2015

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Deciphering the glycolipid code of Alzheimer's and Parkinson's amyloid proteins allowed the creation of a universal ganglioside-binding peptide

J. Fantini & N. Yahi - PLOS One 2014

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Interaction of Alzheimer's beta-amyloid peptides with cholesterol: mechanistic insights into amyloid pore formation

C. Di Scala, H. Chahinian, N. Yahi, N. Garmy, J. Fantini - Biochemistry 2014

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Molecular basis for the glycosphingolipid-binding specificity of alpha-synuclein: key role of tyrosine 39 in membrane insertion

J. Fantini & N. Yahi - J. Mol. Biol. 2011

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Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases

J. Fantini & N. Yahi - Expert Rev Mol Med 2010

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Identification of a common sphingolipid-binding domain in Alzheimer, prion, and HIV-1 proteins

R. Mahfoud , N. Garmy, M. Maresca, N. Yahi, A. Puigserver, J. Fantini - J. Biol. Chem. 2002

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